Hurd's pick six with 3:33 to play capped a 21-point fourth quarter for the Aggies (9-4), who came into the game sharing the No. 21 ranking with the Blue Devils (10-4).
Hurd gave the Aggies their only lead of the game with his 55-yard dash to the end zone. Texas A&M picked off their second pass of the game with 1:18 to play to seal the victory.
Johnny Manziel completed 30-of-38 passes for 382 yards and four touchdowns, all of which came in the second half as the Aggies roared back from a 38-17 halftime deficit. Travis Labhart caught three of Manziel's scoring strikes.
Duke's Anthony Boone also threw for three touchdowns as part of a 427-yard performance and added an 11-yard TD run in the second quarter that staked the Blue Devils to a 21-3 lead. Duke scored only 10 points in the second half.
When the dust settled, Duke had churned out 661 total offensive yards to 541 for the Texans.
Members of Congress to keep receiving porn magazine
Rosie O'Donnell unveils nearly 50-pound weight loss