Mason rushed 32 times for a career high as Auburn (8-1, 4-1 SEC) cruised to a win.
Nick Marshall returned from a shoulder injury sustained last week to go 7-of-8 for 118 passing yards, tossing an 88-yard touchdown pass to Sammie Coates.
The Razorbacks (3-6, 0-5), meanwhile, dropped a sixth straight as Brandon Allen was limited to 10-of-22 passing for 112 yards and a touchdown.
Jonathan Williams and Alex Collins combined for 196 rushing yards for Arkansas.
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