The San Francisco 49ers have been without their top three offensive skill players for the bulk of the season.

The Miami Dolphins aren't making any last-second quarterback changes ahead of Sunday's game against the Detroit Lions.

The unbeaten Los Angeles Rams are on the road again this week to face the 49ers on Sunday in Santa Clara.

San Francisco 49ers left tackle Joe Staley believes that quarterback C.J. Beathard has the team headed in the right direction.

The San Francisco 49ers announced Tuesday that they have signed quarterback Tom Savage to a one-year deal.

It has been three years since the San Francisco 49ers and Green Bay Packers have squared off, but the teams will hook up Monday night at Lambeau Field.

The San Francisco 49ers will take a 1-4 record into Monday night's game against the Green Bay Packers, so they don't need any additional adversity.

The NFL has called an audible, flexing the Cincinnati Bengals' Week 7 road game against the Kansas City Chiefs to national television on Sunday, Oct. 21.

Rookie Josh Rosen threw a 75-yard touchdown pass on the first play from scrimmage as the Arizona Cardinals defeated the San Francisco 49ers.

San Francisco 49ers quarterback Jimmy Garoppolo is expected to be sidelined six-to-eight months after doctors found only a torn ACL when operating on his knee.

The San Francisco 49ers could be without key players on both sides of the ball for Sunday's game against the visiting Arizona Cardinals.

The San Francisco 49ers lost their starting quarterback for the season, both their starting wideouts are banged up and their top running back has been in and out of the lineup with a shoulder injury. Now, following a third loss in four games, the 49ers went back to work Wednesday with three starting offensive linemen watching from the sidelines.

The San Francisco 49ers couldn't pull out the win in their first game minus quarterback Jimmy Garoppolo on Sunday, but their offense was far from stagnant.

The Los Angeles Chargers overcame a double-digit deficit, scoring 20 consecutive points at one point, to pull out a 29-27 win over the San Francisco 49ers.

The San Francisco 49ers traded for Jimmy Garoppolo midway in the 2017 season in what they hoped would be the first building block to turn around the franchise.