The win coupled with Syracuse's loss Tuesday left the Shockers (28-0, 15-0 MVC) as the only unbeaten team left in Div. I men's basketball.
VanVleet also had eight rebounds and Cleanthony Early scored 18 to reach the 1,000-point mark in his college career. Wichita State outrebounded their hosts 41-24 and was a sharp 31-for-34 from the free-throw line.
Milton Anthony scored 18 points to lead Loyola-Chicago (9-18, 4-11). The Ramblers lost their third consecutive game.
Wichita State took a 39-32 lead at halftime and held the Ramblers at arm's length in the second half.