Cameron Clark chipped in 17 points and Jordan Woodard added 15 with eight assists for the Sooners (16-4, 5-2 Big 12), who have won three straight.
Ryan Spangler helped out with seven points and 10 rebounds.
Jaye Crockett and Jordan Tolbert paced Texas Tech (10-10, 2-5) with 14 points apiece.
Alex Foster came off the bench to supply eight points and eight rebounds.
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