Ethan Wragge added 15 points and Devin Brooks supplied 14 for the Bluejays (14-2, 4-0 Big East), who racked up a ninth consecutive victory.
Creighton cleaned up at the free throw line, sinking 17-of-24 attempts en route to the win.
Austin Chatman netted 12 points and Jahenns Manigat put in 11 for the Bluejays.
The Musketeers (13-4, 3-1) were paced by Semaj Christon with 27 points.
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