Ethan Wragge added 15 points and Devin Brooks supplied 14 for the Bluejays (14-2, 4-0 Big East), who racked up a ninth consecutive victory.
Creighton cleaned up at the free throw line, sinking 17-of-24 attempts en route to the win.
Austin Chatman netted 12 points and Jahenns Manigat put in 11 for the Bluejays.
The Musketeers (13-4, 3-1) were paced by Semaj Christon with 27 points.
Chipotle plans first price increase in 3 years
Putin thinks Obama would save him if he were drowning