Clyde Santee and Raphiael Putney each added 13 points for the Minutemen (9-0), who are off to their best start since the 1995-96 team began the season with 26 straight wins.
That squad reached the Final Four but its appearance was vacated due to NCAA penalties.
UMass overcame a slow start to the second half en route to victory, in which it led led nearly the entire way.
The Huskies (3-5) were paced by Dontel Highsmith with 10 points.
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