Moore finished 8-of-8 from the field overall and Tray Woodall added 18 points to go with seven rebounds for the Panthers (24-7, 12-6 Big East).
Pittsburgh shot 71.7 percent from the field in its fourth straight win -- and its last regular-season game as a member of the Big East Conference.
The Panthers, along with Syracuse, will move to the Atlantic Coast Conference next season.
Brandon Young paced the Blue Demons (11-20, 2-16) with 22 points.
NBC reportedly holds celebs hostage to Jimmy Fallon's show
Boston schools pull out free condoms over wrapping complaints