Hillard scored 14 of his points in the second half for the Wildcats (18-10, 9-6 Big East), who bumped off their third ranked opponent in February following earlier triumphs over Louisville and Syracuse.
JayVaughn Pinkston and Ryan Arcidiacono each added 11 points as Villanova won its fifth in six games overall.
Marquette (19-7, 10-4) got only seven points from leading scorer Vander Blue.
Junior Cadoguan managed 12 points for the Golden Eagles, who fell one game behind Big East leader Georgetown.
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