McGruder also hauled down six rebounds and Rodriguez distributed six assists as the Wildcats (22-5, 11-3 Big 12) notched their third straight win following a Feb. 11 loss to Kansas.
The Wildcats broke the game open with an 8-2 run to start the second half.
The Longhorns (12-15, 4-10) got 24 points from Myck Kabongo.
Interpol investigating stolen passports on missing flight
Dennis Rodman pledges to end trips to North Korea