Murphy drained seven of his eight shots and Mike Rosario added 14 points as the Gators (18-2, 8-0 SEC) won their eighth straight in conference play and 10th consecutive overall.
Scottie Wilbekin (13 points, seven assists) and Patric Young (13, 12 rebounds) also played big roles in Florida's win.
The Rebels (17-4, 6-2) got seven 3-pointers and 25 points overall from Marshall Henderson, but it wasn't enough to prevent their second straight loss.
Murphy Holloway provided 15 points and seven rebounds for Mississippi.
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