Nick Johnson provided 13 points, five rebounds and five steals for the Wildcats (7-0), who needed a 20-2 run late in the second half to put the contest away.
Solomon Hill helped out with seven points and 10 rebounds for Arizona.
The Tigers (5-3) got 15 points from Milton Jennings in their second loss in three games.
K.J. McDaniels (13 points) and Adonis Filer (10) also finished in double figures for Clemson.