The four teams will open play against the 16th and final seeds the opening rounds of their respective regional.
Syracuse (31-2) was placed atop the East Region and will face the University of North Carolina at Asheville.
Kentucky (32-2) tops the marquee in the South and will face the winner of Wednesday's play-in game between Western Kentucky and Mississippi Valley State.
Michigan State (27-7) heads to the West and opens against New York's Long Island State University-Brooklyn.
North Carolina (29-5) is top seed in the Midwest and faces the winner of the Lamar vs. Vermont play-in.
Kentucky and North Carolina were given top regional seeds despite losing in their conference finals Sunday. The Wildcats fell to Vanderbilt 71-64 in the Southeastern Conference Tournament title game and Florida State won the Atlantic Coast Conference championship with an 85-82 win over Carolina.
Michigan State won the Big Ten Conference title Sunday with a 68-64 win over Ohio State.
Ohio State was seeded second in the East Region and Kansas was seeded No. 2 in the Midwest. Duke is seeded second in the South and Missouri got the No. 2 seed in the West.
Baylor, Florida State, Georgetown and Marquette are the No. 3 seeds. The fourth seeds went to Indiana, Wisconsin, Michigan and Louisville.
Defending NCAA champion Connecticut (20-13) was seeded ninth in the South Region.
March Madness play commences Tuesday with play-ins between Mississippi Valley State and Western Kentucky, and Iona vs. Brigham Young. The title game will be played April 2 in New Orleans.