Duke (15-2, 3-0 ACC) notched its third consecutive win with 12 points and seven rebounds from Mason Plumlee.
Miles Plumlee hauled down 14 rebounds and Quinn Cook added 10 points for the Blue Devils.
Clemson (9-8, 1-2) was led by Milton Jennings with 16 points, while Devin Booker and Andre Young each added 12.
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