Ohio State made 46-of-68 shots from the field and hit on half of its 10 3-point attempts.
Buford added six assists while Jared Sullinger had 17 points and 12 rebounds for the Buckeyes (5-0).
The only margin of victory less than 30 points for Ohio State this season came in a seven-point decision over Florida.
The Buckeyes owned a 57-44 halftime lead and then held the Keydets scoreless during a 4-minute stretch early in the second half.
Keith Gabriel paced VMI (3-2) with 21 points.