San Francisco 49ers defender Nick Bosa got "payback" on Cleveland Browns quarterback Baker Mayfield on Monday Night Football, mimicking a celebration the former Oklahoma star performed against Bosa's Ohio State Buckeyes.

The San Francisco 49ers are now 4-0 after cruising to a 31-3 victory against the Cleveland Browns on Monday Night Football.

San Francisco 49ers running back Tevin Coleman is expected to miss multiple games after suffering a high left ankle sprain.

The San Francisco 49ers released veteran linebacker and former Super Bowl MVP Malcolm Smith after two injury-plagued seasons.

Denver Broncos wide receiver Emmanuel Sanders looked great in his return from a torn Achilles while San Francisco 49ers quarterback Jimmy Garoppolo struggled in a preseason clash at Broncos Stadium at Mile High.

San Francisco 49ers starting quarterback Jimmy Garoppolo struggled during the team's practice Wednesday, throwing five consecutive interceptions.

San Francisco 49ers rookie defensive end Nick Bosa sustained a "significant" ankle injury, according to general manager John Lynch.

San Francisco 49ers wide receiver Marquise Goodwin says he wants to compete in the 2020 Olympics.

San Francisco 49ers rookie defensive lineman Nick Bosa suffered a hamstring injury during practice Tuesday.

The Washington Redskins are the betting favorite to be the next team featured on HBO's "Hard Knocks."

The Pittsburgh Steelers haven't spoken to the San Francisco 49ers regarding Antonio Brown, despite the wide receiver's interest in the Bay Area franchise.

Jerry Rice wants the San Francisco 49ers to go after disgruntled Pittsburgh Steelers wide receiver Antonio Brown via trade.

The San Francisco 49ers gave up a lot of points and did not force many turnovers, but Robert Saleh will return for his third season as the 49ers' defensive coordinator, coach Kyle Shanahan said Monday.

The Atlanta Falcons fired offensive coordinator Steve Sarkisian, defensive coordinator Marquand Manuel and special teams coordinator Keith Armstrong.

The Los Angeles Rams' 31-9 victory over the Arizona Cardinals last weekend was important because it snapped a two-game losing streak.