San Francisco 49ers wide receiver Pierre Garcon will have arthroscopic knee surgery on Tuesday and will be placed on season-ending injured reserve, coach Kyle Shanahan said.

The Denver Broncos are trying to keep pace in the AFC playoff race while scrambling to find replacements for two injured players ahead of their game Sunday against the host San Francisco 49ers.

The San Francisco 49ers will be without leading rusher Matt Breida for at least Sunday's game vs. the Denver Broncos with an injured ankle.

When the schedule was issued before the season, Sunday's game in Seattle against the San Francisco 49ers seemed intriguing since it would be the return of Richard Sherman.

An indication that Tampa Bay would turn things around against San Francisco on Sunday occurred when the Buccaneers had a dramatic goal-line stand at the beginning of the second half ahead by only a touchdown.

Jameis Winston threw for 312 yards and two touchdowns, and the Tampa Bay defense corralled the San Francisco offense to beat the 49ers 27-9 on Sunday.

The revolving door at quarterback in Tampa Bay took another spin this week and Jameis Winston will start when the Buccaneers host the San Francisco 49ers.

The New York Giants take on the San Francisco 49ers in Santa Clara in a battle of cellar dwellers on Monday night.

Nick Mullens told reporters Tuesday that San Francisco 49ers head coach Kyle Shanahan informed Mullens that he will start Monday's game.

An outstanding night by the San Francisco 49ers was tarnished by an ugly injury to Raheem Mostert.

Nick Mullens' superb Week 9 performance means a tough decision is ahead for Kyle Shanahan when it comes to naming the San Francisco 49ers' Week 10 quarterback.

The San Francisco 49ers could be down to their third-string quarterback on Thursday Night Football against the Oakland Raiders.

There's a lot at stake when the San Francisco 49ers host the Oakland Raiders on Thursday, but for all the wrong reasons.

A sixth consecutive loss and seventh in eight games on Sunday has the San Francisco 49ers looking to shed some players ahead of the trade deadline on Tuesday.

Arizona Cardinals quarterback Josh Rosen hit Christian Kirk for a touchdown with 34 seconds left as the Cardinals rallied to beat the San Francisco 49ers.