Justin Jefferson, Tyreek Hill, A.J. Brown, CeeDee Lamb and Keenan Allen round out my top 10 options for Week 2. Brandin Cooks, Christian Kirk and Mike Williams are among my other favorite wide receivers to start this week.
Target players who have a good chance to score a touchdown and get a lot of looks from their respective quarterbacks when considering who to start at wide receiver.
Here are some of my favorite players in this week's rankings:
Metcalf is a threat to score twice and lead all wide receivers in fantasy points. He is No. 1 in my rankings.
The Green Bay Packers logged one of the most disappointing performances in Week 1, losing 38-3 to the New Orleans Saints. Look for a big time rebound from Packers quarterback Aaron Rodgers and wide receiver Davante Adams in Week 2.
The Packers host the Detroit Lions, who are coming off a brutal loss in Week 1. The Lions also lost top cornerback Jeff Okudah to a season-ending injury last week.
Rodgers and the Packers should dominate this matchup. Adams is my No. 2 wide receiver for Week 2. I expect at least 100 receiving yards and two scores from Rodgers' top target.
Mike Evans posted a pedestrian three catches for 24 yards and didn't score in the Tampa Bay Buccaneers' Week 1 win, but should be more involved in Week 2.
The Falcons also owned one of the worst pass defenses in the NFL last season.
Buccaneers quarterback Tom Brady should carve up this secondary. Evans should find the end zone and reel in at least six catches in a lopsided victory. He is my No. 5 wide receiver.
Texans quarterback Tyrod Taylor threw for 291 yards and two scores in Week 1, with wide receiver Brandin Cooks as his top target. Cooks, who secured five catches for 132 yards against the Jaguars, should find room again in Week 2 against the Cleveland Browns.
Look for Cooks to find the end zone for his first touchdown of the season Sunday in Cleveland. He is my No. 24 option and can be used as a low-end WR2 or high-end WR3.
Arizona Cardinals wide receiver Christian Kirk was one of my top waiver wire pickups for Week 2. He lands at No. 27 in my Week 2 rankings and can be used as a WR3 in all leagues.
Cardinals quarterback Kyler Murray looks like an early NFL MVP contender on what should be an explosive offense all season.
DeAndre Hopkins remains Murray's top target, but don't be shocked to see Kirk post WR1 level fantasy football stats throughout the year when he gets a good matchup.
Kirk secured each of his five targets for 70 yards and two touchdowns in a Week 1 win over the Tennessee Titans. This week, he faces a Minnesota Vikings defense that just allowed 101 yards and a score on five catches to Cincinnati Bengals rookie Ja'Marr Chase.
The speed of Hopkins and Kirk should overwhelm the Vikings in Week 2. I expect both players to reach the end zone for a second-consecutive week.
Mike Williams of the Los Angeles Chargers scored his team's lone receiving touchdown in a Week 1 win over the Washington Football Team. He is my No. 36 wide receiver in Week 2.
The Chargers host the Dallas Cowboys on Sunday in Inglewood, Calif. Tampa Bay Buccaneers quarterback Tom Brady threw for 379 yards and four scores in a Week 1 win over the Cowboys.
Look for Chargers quarterback Justin Herbert to throw at least three touchdown passes in what should be a shootout in Week 2.
I expect Williams to catch at least six passes for 100 yards, with a chance to score.
Week 2 fantasy football wide receiver rankings
1. D.K. Metcalf, Seattle Seahawks vs. TEN
2. Davante Adams, Green Bay Packers vs. DET
3. DeAndre Hopkins, Arizona Cardinals vs. MIN
4. Stefon Diggs, Buffalo Bills at MIA
5. Mike Evans, Tampa Bay Buccaneers vs. ATL
6. Justin Jefferson, Minnesota Vikings at AZ
7. Tyreek Hill, Kansas City Chiefs at BAL
8. A.J. Brown, Tennessee Titans at SEA
9. CeeDee Lamb, Dallas Cowboys at LAC
10. Keenan Allen, Los Angeles Chargers vs. DAL
11. Calvin Ridley, Atlanta Falcons at TB
12. Antonio Brown, Tampa Bay Buccaneers vs. ATL
13. Cooper Kupp, Los Angeles Rams at IND
14. Tyler Lockett, Seattle Seahawks vs. TEN
16. Julio Jones, Tennessee Titans at SEA
17. Robert Woods, Los Angeles Rams at IND
18. DeVonta Smith, Philadelphia Eagles vs. SF
19. Amari Cooper, Dallas Cowboys at LAC
20. Ja'Marr Chase, Cincinnati Bengals at CHI
21. Adam Thielen, Minnesota Vikings at AZ
22. D.J. Moore, Carolina Panthers vs. NO
23. Diontae Johnson, Pittsburgh Steelers vs. LV
24. Brandin Cooks, Houston Texans at CLE
25. Chris Godwin, Tampa Bay Buccaneers vs. ATL
26. Robby Anderson, Carolina Panthers vs. NO
27. Christian Kirk, Arizona Cardinals vs. MIN
28. Chase Claypool, Pittsburgh Steelers vs. LV
29. Jarvis Landry, Cleveland Browns vs. HOU
31. Marquez Callaway, New Orleans Saints at CAR
32. Brandon Aiyuk, San Francisco 49ers at PHI
33. Laviska Shenault Jr., Jacksonville Jaguars vs. DEN
34. Tyler Boyd, Cincinnati Bengals at CHI
35. Deebo Samuel, San Francisco 49ers at PHI
36. Mike Williams, Los Angeles Chargers vs. DAL
37. Jaylen Waddle, Miami Dolphins vs. BUF
38. Tee Higgins, Cincinnati Bengals at CHI
39. JuJu Smith-Schuster, Pittsburgh Steelers vs. LV
40. Jalen Reagor, Philadelphia Eagles vs. SF
41. DeVante Parker, Miami Dolphins vs. JAX
42. Henry Ruggs III, Las Vegas Raiders at PIT
43. Jakobi Meyers, New England Patriots at NYJ
45. Mecole Hardman, Kansas City Chiefs at BAL
46. Tim Patrick, Denver Broncos at JAX
47. Amon-Ra St. Brown, Detroit Lions at GB
49. Marquez Valdes-Scantling, Green Bay Packers vs. DET
50. Anthony Schwartz, Cleveland Browns vs. HOU