Brie, best known for starring in Community and Glow, starting trending on Twitter recently due to Marvel's casting call. Fans started to ask Brie to be cast in the role as opposed to an Alison Brie-type actress.
Corden asked Brie if she was in talks to portray the superhero but she denied any involvement with the project despite being intrigued by the role.
"I find it interesting," she said about appearing as She-Hulk.
Brie, who recently starred in Netflix's Horse Girl, will next star in romantic comedy Happiest Season.