Isaac Stern (Ukrainian: Стерн Ісаак; July 21, 1920 – September 22, 2001) was a Jewish violin virtuoso born in Ukraine.

He was renowned for his recordings and for discovering new musical talent.

Stern was born in Kremenetz, Ukraine. He was fourteen months old when his family moved to San Francisco. He received his first music lessons from his mother before enrolling at the San Francisco Conservatory of Music in 1928 where he studied until 1931 before going on to study privately with Louis Persinger. He returned to the San Francisco Conservatory to study with Naoum Blinder for five years. He said he owed the most to Blinder. At his public début on February 18, 1936, aged 15, he played the Violin Concerto No. 3 in B minor of Camille Saint-Saëns with the San Francisco Symphony under the direction of Pierre Monteux. Reflecting on his background Stern once memorably quipped that cultural exchanges between the US and Soviet Russia were simple affairs: "They send us their Jews from Odessa, and we send them our Jews from Odessa."