Calderoli, a member of the Northern League party, has been charged with defamation aggravated by racial discrimination, the ANSA news agency reported.
The charges stem from a statement he made about Italy's integration minister, Cecile Kyenge, an opthalmologist born in the Democratic Republic of Congo. She is the first back to serve in the Italian Cabinet.
''Whenever I see Minister Kyenge, I cannot help but think of an orangutan," Calderoli said to fellow party members in July.
Prosecutors called for an immediate trial Wednesday, ANSA said.