Furyk and Snedeker's 1-up victory over the highly touted European tandem of world No. 1 Rory McIlroy and Graeme McDowell finished a run of three straight U.S. foursome wins in the morning session at Medinah Country Club.
Phil Mickelson and Keegan Bradley improved to 3-0 for the week with a 7 & 6 drubbing of Luke Donald and Lee Westwood, while Jason Dufner and Zach Johnson posted a 2 & 1 victory over Sergio Garcia and Nicolas Colsaerts.
That gave the United States a four-point lead, which it retained following a split in the afternoon four-ball sessions.
Europe, however, stayed somewhat within striking distance by taking the final two events.
Ian Poulter used five birdies over the last five holes to give himself and McIlroy a 1-up victory over Dufner and Johnson, while the tandem of Luke Donald and Sergio Garcia registered a 1-up decision over Tigers Woods and Steve Stricker.
The Europeans, however, need to equal the biggest comeback in Ryder Cup history Sunday to pull out a victory.