Less than a minute into the contest, Wilkins was engaged with Ford on a block. The two got into a scuffle during the play, which ended with Wilkins appearing to swing and connect with Ford's helmet.
Wilkins was immediately penalized and disqualified from the game. The punch came on the second play of the matchup.
Wilkins' ejection marked the eighth disqualification of an NFL player from a game during this season, tied for the most through seven weeks in the last 15 seasons.
Following Wilkins' ejection from the game, the Bills scored a field goal on their opening offensive possession. Buffalo held a 17-14 lead over the Dolphins with 11:05 left in the fourth quarter.
Wilkins, who was drafted with the No. 13 overall pick out of Clemson, has started every contest on the defensive line this season.