Murray is not expected to play because of a knee injury, according to an NFL Network report Monday.
Murray is the Titans' No. 1 back and has rushed for 659 yards on 184 carries. But the team's leading rusher is Derrick Henry, who has 693 yards on 148 carries.
Over the past three games, however, Murray has carried 44 times for 141 yards, while Henry has had 23 rushing attempts for 64 yards.