The comedians donned wigs and makeup to become Biden and Harris before they posed together back-to-back in the teaser released on Twitter Thursday.
Woody Harrelson previously portrayed Biden during Season 45. Jason Sudeikis has also starred as the former vice president in past seasons.
NBC will be bringing Saturday Night Live back to Studio 8H in New York starting with Season 46. The premiere will be the show's first in-studio episode since March 7 due to the COVID-19 pandemic.