The 50-year-old actress shared a photo Thursday with Reynolds and his daughter Inez from a night at the actor and his wife Blake Lively's house.
"When your friends invite you for dinner and you end up doing all the work #hitmansbodyguard #ryanreynolds #tbt," she captioned the picture on Instagram.
Hayek and Reynolds will co-star in the new film The Hitman's Bodyguard, which opens in theaters Aug. 18. The actress previously co-starred with Lively in a 2012 adaptation of the Don Winslow novel Savages.
"Now that I'm older, I don't get [the sexy sidekick roles] as much," she said of her Hitman's Bodyguard character in the spring issue of DuJour.
"I did my own stunts," the star confirmed. "They said, 'We have a stunt double, and some of the things are quite hard.' And I said, well, let's give it a try.' And guess what? I can still kick really high! Mind you, the next morning I was full of bruises and I couldn't move for two weeks but, man, did I show off that day!"
Reynolds and Lively share 10-month-old Inez and 2-year-old daughter James, while Hayek is parent to 9-year-old daughter Valentina with husband Francois-Henri Pinault. The actress told DuJour her family comes first over her career.
"I just take it one day at a time, I don't do strategy," she said. "The most important thing in my life is my family, easily. I've never been away from my daughter for more than two weeks. Sometimes I do a movie [just] because I like the people."