The Thunder led by 12 heading into the final period and eventually won their eighth in a row. Oklahoma City is 13-0 on its own court this season, the only team in the NBA without a home loss.
Durant also had nine rebounds and six assists, making 13-of-20 shots from the field and hitting four 3-pointers.
Over his last four games Durant has averaged 30.2 points per contest while making 60 percent of his attempts from the field. He leads the league in scoring with an average of 28.6 points per game.
Joakim Noah had a season-best 23 points for the Bulls, who have lost four in a row. The Bulls' Luol Deng did not play due to a sore Achilles tendon that also caused him to miss four games earlier this month. Kirk Hinrich was out of action for a fourth straight game due to back problems.