Bryant connected on 9-of-14 shots, including a trio of 3-pointers, and Howard hauled down 14 rebounds for the Lakers, who led wire-to-wire in logging their first win of January.
Antawn Jamison canned four treys en route to 16 points and Darius Morris supplied 14 points as Los Angeles shot a sizzling 58 percent from the field.
Kyrie Irving contributed 15 points and seven assists, and Dion Waiters also scored 15 points for the Cavaliers, who fell to 5-18 on the road.
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