The "Medium" star and "Hung" actor decided to get a divorce, despite working through a separation last year, the rep said. Arquette first filed for divorce from Jane in January 2009, but the two reconciled later in the year, the report said.
The rep added, "The split is completely amicable and their prime focus is their daughter. They ask that their privacy be respected at this time."
Arquette and Jane met through friends, and were married in Italy in May 2006, People said. Their only child together, Harlow Olivia Calliope, was born in February 2003.
Celebrity Families of 2014 [PHOTOS]