"The game works exactly like Pictionary except the person who is drawing will be wearing one of these virtual reality headsets," Fallon explained of the new late night game that debuted in December.
"You're going to draw in 3D space using this program called Tilt Brush. It's so rad! We're going to be able to see what you're drawing on the big screen behind us," he continued to his guests.
Fallon and Cameron were up first with the Disney Channel star successfully able to guess that her partner was drawing a clown car.
Johansson and Che were also successful when the Saturday Night Live comedian was able to determine that the actress was drawing a pinball machine.
"Whoa, this is trippy!" Johansson said after she adjusted her VR headset.
In the final round, both teams failed to guess that Che was drawing a spring chicken in order to win the game.
Johansson will next be seen starring in anime adaptation Ghost in the Shell which arrives in theaters Friday.