Cooper and Ripa appeared on the Bravo television show, hosted by mutual friend Andy Cohen, and things got a little personal.
Cohen instructed Cooper and Ripa to sit face to face and rapid-fire questions at each other. The first person to get frustrated or embarrassed loses.
Ripa asked Cooper if he was circumcised, if he wanted to have sex and if he wanted to see her vagina.
"I'm getting flustered, you're flustering me," Cooper said with a giggle.
"When she said 'vagina,' that's when I had to stop. I got very nervous," he added.