Actress Wendie Jo Sperber dead at 46

LOS ANGELES, Nov. 30 (UPI) -- Actress Wendie Jo Sperber, best known for starring in TV's "Bosom Buddies" with Tom Hanks, has died of breast cancer at age 46.

Sperber died Tuesday night after a long battle against the disease, her publicist told "Entertainment Tonight."

Sperber most recently guest-starred on NBC's "Will & Grace," "ET" said.

She founded the weSPARK Cancer Support Center in Sherman Oaks, Calif., in 2001.

"The memory of Wendie Jo is that of a walking inspiration," Hanks said in a statement. "She met the challenges of her illness with love, cheer, joy, altruism through weSPARK, and an unstoppable supply of goodness. We are going to miss her as surely as we are all better for knowing her."