The 39-year-old comedy writer and actor tweeted Monday that that he was too busy with other projects to host the Oscars next year.
"Traumatized critics exhale: I'm unable to do the Oscars again. Tried to make it work schedule-wise, but I need sleep," MacFarlane said.
"However, I highly recommend the job, as Zadan and Meron are two of the most talented producers in the business," he continued.
He put forward his own thoughts on next year's host: "My suggestion for host is Joaquin Phoenix."
Watch MacFarlane's opening monologue from this year's Oscars ceremony below: