Saeed, 61, a Pakistani militant, is suspected of masterminding numerous terrorist attacks, including the 2008 Mumbai attacks which resulted in the deaths of 166 people, including six American citizens, the U.S. State Department's Rewards for Justice Web site said.
Saeed is a former professor and the founding member of Jamaat-ud-Dawa, a radical Deobandi Islamist organization, and its military branch, Lashkar-e-Tayyiba. Both groups have been declared terrorist organizations by the United States, the Web site said.
India has been pressing for the arrest of Saeed, who lives openly in Lahore, in eastern Pakistan, The New York Times said.
The Times said the reward is likely to further strain U.S. relations with Pakistan.