President Obama named the group that will receive the nation's highest civilian honor this year on the 50th anniversary of President John F. Kennedy's executive order establishing the medal.
Clinton, the 42nd U.S. president, was cited for creating the Clinton Foundation to improve world health, wellness and the environment, and his relief efforts for Haiti with former President George W. Bush after the 2010 earthquake that devastated the Caribbean island nation.
Former talk show queen Winfrey, a Kennedy Center honoree in 2010, has long been active in philanthropic causes and programs to help young women.
Steinem, a writer and women's rights activist, co-founded Ms. magazine and was a leader in the women's equality movement.
Other honorees include former University of North Carolina head basketball coach Dean Smith, former Washington Post executive editor Ben Bradley, late U.S. Sen. Daniel Inouye, D-Hawaii., pioneer psychology scholar Daniel Kahneman, former U.S. Sen. Richard Lugar, R-Ind., country music legend singer Loretta Lynn, chemist and environmental scientist Mario Molina; late astronaut Sally Ride, the first U.S. female astronaut to travel in space, late civil rights activist Bayard Ruskin, jazz trumpeter, pianist and composer Auturo Sandova, minister and civil rights organizer Rev. Cordy Tindell "C.T." Vivian and former Chief U.S. Appellate Judge Patricia Wald, the first woman appointed to the U.S. Circuit Court of Appeals for the District of Columbia.
"The Presidential Medal of Freedom goes to men and women who have dedicated their own lives to enriching ours," said Obama in a statement. "This year's honorees have been blessed with extraordinary talent, but what sets them apart is their gift for sharing that talent with the world."