About 400 people set off from London Friday, while another 500 joined along the way in meet in Aldermaston, England, in a repeat of the first peace march there in 1958, the BBC reported.
The Atomic Weapons Establishment at Aldermaston is responsible for the design and manufacture of the of the Trident submarine-launched intercontinental ballistic missile system.
Marchers blew whistles and banged saucepans as they formed a six-mile human chain around the base in a protest of a new generation of arms being developed.
"We were stepping out with the aim of sending a message that we don't want new nuclear weapons in Britain and we feel we are well on the way to doing that," said Kate Hudson, one of the march organizers.
A Ministry of Defense spokesman refused to comment on the weapons program, but said, "We acknowledge the right to peaceful and lawful demonstration."
Forty-six years ago, about 10,000 people marched from London to Aldermaston in protest at Britain's first hydrogen bomb tests.