Hibbert supplied 14 points, 12 rebounds and four blocks for the Pacers, who topped Denver for the first time in six meetings.
Lance Stephenson and Paul George each added 12 points in the rout.
The Nuggets, playing without leading scorer Ty Lawson (fractured rib), fell to 0-3 on a four-game road trip.
2014: The Year in Fashion [PHOTOS]
UPI Sports Results for September 19, 2014