The Spurs have lost three in a row for the first time this season and have dropped four of five.
San Antonio played without guard Manu Ginobili, who could be out for a month with a strained hamstring. Danny Green, Kawhi Leonard and Tiago Splitter, all part of the group that helped carry the Spurs to the NBA finals a season ago, are also out of action.
Chicago opened as much as a 14-point lead in the fourth period after owning a seven-point advantage heading into the final quarter.
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