Travis Hafner followed by blasting game-tying, pinch-hit homer off right field foul pole, sending the contest into extra innings.
In the 12th, Lonnie Chisenhall stroked a one-out double off Matt Thornton (4-10), and after Russ Canzler was intentionally walked, Nate Jones came in to pitch.
Donald greeted him with line shot into left field for the decisive blow.
The hit made a winner of Chris Seddon (1-1) as the Tribe evened their season-ending three-game series.
Dayan Viciedo belted a two-run homer for Chicago.
Charlize Theron not engaged to Sean Penn 'yet'
Pregnant Mila Kunis wins 'Best Villain' at MTV Movie Awards