The Bulls, who will go into the playoffs as the No. 1 seed in the entire NBA, will take on Philadelphia Saturday in the opener of their first-round series.
Chicago finished the regular campaign with a 50-16 record, winning its third in a row. The Cavaliers wound up their season with three straight losses and put up little resistance against the Bulls.
Lucas hit 10-of-16 shots from the field and Chicago made 54 percent of its attempts. Joakim Noah added 13 points and Jimmy Butler had 12.
Last season's league MVP Derrick Rose sat out for the 27th time in Chicago's 66 games this season. He is expected to be in the lineup when the playoffs begin.
Tristan Thompson led Cleveland with 13 points. The Cavaliers finished in last place in the Central Division with 21 wins -- 15 games out of the playoffs.