Igoudala added seven rebounds, four assists and three steals for the Sixers, who are off to the best start on their home court since going 10-0 in 2000-01.
Lou Williams came off the bench to net 17 points and the Sixers went 11-of-23 from 3-point territory in the victory.
Milwaukee, meanwhile, extended its worst road start since 1976-77, falling to 0-8 away from home.
Andrew Bogut led the Bucks with 20 points and 11 rebounds in his return to the lineup after suffering a concussion.
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