The defending Western Conference champion Canucks snapped a two-game skid, twice coming from a goal behind and then winning it by producing the only goal of the final period.
Vancouver overcame a hat trick by Ryan Nugent-Hopkins, who scored his second, third and fourth goals of the season.
The final goal from Nugent-Hopkins gave Edmonton a 3-2 lead with 3:23 to play in the second, but Alex Burrows tied it 16 seconds before the end of the period by tipping in a shot.
It stayed 3-3 until Salo put a wrist shot past Devan Dubnyk, who had won his only other start this season.
Roberto Luongo allowed three goals on 29 shots. Dubnyk made 24 saves.
Justin Bieber crashes Drake Bell's album release party
Putin thinks Obama would save him if he were drowning