It was New England's 11th straight win.
The Patriots (13-2) moved one game ahad of Kansas City, which lost earlier Saturday, and clinched a first-round bye in the playoffs. They could clinch home-field with a win next weekend against Buffalo.
New England's winning streak is the longest in th NFL since Indianapolis and Jacksonville also won 11 in a row in 1999.
On New York's first possession, Pennington was picked off by linebacker Tedy Bruschi. Brady immediately capitalized, hitting Givens with a 35-yard touchdown 48 seconds into the game.
Pennington had more success with his legs than with his arm, running for a pair of touchdowns.
The loss assured the Jets (6-9) of thir first losing season since 1996.