Suleman became the polarizing media figure known as "Octomom" after she gave birth in 2009 to octuplets she conceived via fertility treatments and had no financial means to support them.
The Orange County (Calif.) Register said Monday Suleman now owes a $450,000 balloon payment on her La Habra, Calif., home.
She will appear on Friday's edition of "Oprah" to learn how she can keep the house out of foreclosure, Oprah.com said Monday.
"Controversial Octomom Nadya Suleman says she's financially destitute. Now, Suze Orman intervenes," the Web site said.