Also confirmed for the event are former "Lost" co-stars Harold Perrineau, Henry Ian Cusick and Jorge Garcia, as well as the series' creators Carlton Cuse and Damon Lindelof. The show ended in May after six seasons.
The Scream 2010 awards presentation is to include a musical performance by singer M.I.A. and a tribute to the iconic 1980s movie "Back to the Future" and its stars Michael J. Fox and Lea Thompson.
The program is to air on the network Oct. 19.