The network revealed Majors is to play God and Estrada the Devil in the June 2 episode of the sit-com called "Heaven Opposed to Hell." In it, main character Jim, played by Jim Belushi, chokes on a shrimp puff, dies and arrives at Heaven's gate.
"With Jim on trial to prove his selfless acts on earth, best friend Andy is summoned to heaven to defend him," ABC said in a news release. "As Jim attempts to prove his good works to God, his sister-in-law, Dana, represents the Devil, arguing that Jim's selfishness should mean a certain trip to hell."
Larry Joe Campbell plays Andy and former series regular Williams-Paisley reprises her role of Dana.
Aykroyd, who is Belushi's real-life friend and frequent collaborator, has appeared several times on "Jim" as character Danny. He will return again in the role for the season ender, ABC said.