Hoffman is expected to attend the Oct. 5 Chicago Theatre's opening night screening of "Fiction," the Chicago Tribune reported Thursday.
The Marc Forster film is about a novelist played by Emma Thompson, whose main character, played by Will Ferrell, takes on a life of his own. Hoffman plays a literature professor who aids the fictional character's quest for survival.
"I'm really proud of it," Hoffman said, adding that he has "only said that about three times during my career."
The 42nd Chicago International film festival is running Oct. 5-19 and showcasing more than 100 features from more than 30 countries.