The biggest price reduction, 20 percent, is on the flagship 16-gigabyte Nook, as the 7-inch, full-color touch tablet has been marked down from $249 to $199 to compete with the Kindle Fire.
Smaller discounts are being offered on the 8-gigabyte Nook Tablet and the Nook Color, the company said in a release Monday.
That makes the company's tablets "available for the lowest prices ever," Jamie Iannone, president of the company's digital products group, said in a statement.
Nook owners can access more than 2.5 million book titles as well as movies and television shows from Netflix and other content partners, Barnes & Noble said.
In an agreement announced in April, Barns & Noble will spin off its e-book and e-reader business into a new subsidiary with Microsoft as a partner.
As part of the deal Barnes & Noble said it would develop a Nook-branded e-reader app for use on Windows 8 PCs and tablets, including Microsoft's own Surface tablet.