Walgreen said the layoffs planned for 2009 should save about $350 million per year for the next two years, the Chicago Tribune reported.
Walgreen said the cuts involve field managers and corporate workers who are not store workers.
The first phase of the layoffs would be handled through a voluntary program followed by an "involuntary separation program," starting in February.
Jordana Brewster on Paul Walker: 'He was an enormous presence in my life'
Benedict Cumberbatch's dramatic reading of R. Kelly lyrics is just what you need