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Lee Loughnane (pronounced LOCK-nane) (born 21 October 1946, in Elmwood Park, Illinois) is an American trumpeter, flugelhorn player, vocalist, and songwriter, best known for being a founding member of the rock band Chicago.

Loughnane was influenced by his father Philip (also a trumpeter).

Through his friendship with guitarist Terry Kath, Loughnane met drummer Danny Seraphine and saxophone/woodwind player Walter Parazaider. Parazaider, who was trying to form a rock 'n roll band with horns, encouraged Loughnane to sit in on rehearsals. At first, the group was known as The Big Thing. Eventually it became The Chicago Transit Authority (later renamed Chicago) with the addition of members James Pankow (trombone), Robert Lamm (keyboards), and Peter Cetera (bass). Loughnane has continued to be a member of Chicago since its inception.

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