With Brady and Mahomes sharing the cover of the popular football video game, it marks the first time two players are on the game's front in more than a decade. The last time that occurred was Madden NFL 10, which featured Pittsburgh Steelers great Troy Polamalu and Arizona Cardinals wide receiver Larry Fitzgerald on the cover.
"Whenever you first get on the cover, that's a special moment," Mahomes told ESPN. "So to be on it again, twice, with an all-time great like Tom Brady, it's a special moment that I'm glad I'm able to do so soon after I had done it the first time.
"I'll be able to have it for the rest of my life and be able to show my kids and my kids' kids that I was on it two times."
Mahomes made his first cover appearance on Madden NFL 20. Brady's first cover was on the 2018 edition of the game.
"To think that now, almost 30 years later, 25 years later, since the mid-'90s, here I am representing EA on the cover of Madden with one of the other great players in the NFL right now," Brady said. "And just thinking how fortunate I've become over the years to put myself in this position to have these experiences in my life that I'm very grateful for.
"So it's a really cool thing. It's definitely a huge honor, and getting to do it with Patrick and the career he's had has been exceptional."
Madden NFL 22 -- which will have standard, deluxe and MVP editions -- is scheduled to release on Aug. 20 for Xbox Series X/S, PlayStation 5, PS4, Xbox One, PC and more.